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Assay Detail

CHEMBL618695

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Binding
Binding affinity for rat 5-hydroxytryptamine 2A receptor using [3H]DOB
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 2A (CHEMBL322)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Binding of beta-carbolines at 5-HT(2) serotonin receptors.
Grella B, Teitler M, Smith C, Herrick-Davis K, Glennon RA.
Bioorg Med Chem Lett (2003) 13 : 4421 -4425
PubMed 14643338 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 11 6.42 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL6857 1 7.68
CHEMBL6586 1 7.12
CHEMBL6426 1 7.10
CHEMBL6746 1 6.94
CHEMBL269571 1 6.40
CHEMBL6591 1 6.30
CHEMBL266084 1 5.85
CHEMBL6310 1 5.66
CHEMBL269367 1 5.59
CHEMBL269236 TRYPTOLINE 1 5.52
CHEMBL6409 CGS-19281A 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL6857 Ki = 21.0 nM 7.68
CHEMBL6586 Ki = 75.0 nM 7.12
CHEMBL6426 Ki = 80.0 nM 7.10
CHEMBL6746 Ki = 115.0 nM 6.94
CHEMBL269571 Ki = 400.0 nM 6.40
CHEMBL6591 Ki = 500.0 nM 6.30
CHEMBL266084 Ki = 1400.0 nM 5.85
CHEMBL6310 Ki = 2200.0 nM 5.66
CHEMBL269367 Ki = 2550.0 nM 5.59
CHEMBL269236 TRYPTOLINE Ki = 3000.0 nM 5.52
CHEMBL6409 CGS-19281A Ki > 10000.0 nM -