Assay Detail
Binding
CHEMBL618895
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Binding affinity towards rat 5-hydroxytryptamine 2A receptor expressed in NIH3T3 cells using [3H]ketanserin as radioligand
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | NIH3T3 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 32 | 6.98 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129230 | — | — | 1 | 8.22 |
| CHEMBL129163 | — | — | 1 | 7.80 |
| CHEMBL126438 | — | — | 1 | 7.70 |
| CHEMBL129476 | — | — | 1 | 7.66 |
| CHEMBL96504 | — | — | 1 | 7.52 |
| CHEMBL128185 | — | — | 1 | 7.42 |
| CHEMBL126138 | — | — | 1 | 7.42 |
| CHEMBL424258 | — | — | 1 | 7.30 |
| CHEMBL128099 | — | — | 1 | 7.30 |
| CHEMBL446356 | — | — | 1 | 7.22 |
| CHEMBL130586 | — | — | 1 | 7.19 |
| CHEMBL341506 | — | — | 1 | 7.19 |
| CHEMBL128848 | — | — | 1 | 7.16 |
| CHEMBL340646 | — | — | 1 | 7.00 |
| CHEMBL126898 | — | — | 1 | 6.94 |
| CHEMBL2111848 | — | — | 1 | 6.92 |
| CHEMBL128184 | — | — | 1 | 6.92 |
| CHEMBL338095 | — | — | 1 | 6.89 |
| CHEMBL125417 | — | — | 1 | 6.89 |
| CHEMBL126823 | — | — | 1 | 6.82 |
| CHEMBL338696 | — | — | 1 | 6.80 |
| CHEMBL126994 | — | — | 1 | 6.76 |
| CHEMBL125361 | — | — | 1 | 6.73 |
| CHEMBL126897 | — | — | 1 | 6.71 |
| CHEMBL126737 | — | — | 1 | 6.68 |
| CHEMBL338081 | — | — | 1 | 6.65 |
| CHEMBL130585 | — | — | 1 | 6.55 |
| CHEMBL435814 | — | — | 1 | 6.54 |
| CHEMBL128945 | — | — | 1 | 6.38 |
| CHEMBL340511 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129230 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL129163 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL126438 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL129476 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL96504 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL128185 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL126138 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL424258 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL128099 | — | Ki | = | 50.0 | nM | 7.30 |
| CHEMBL446356 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL130586 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL341506 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL128848 | — | Ki | = | 70.0 | nM | 7.16 |
| CHEMBL340646 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL126898 | — | Ki | = | 115.0 | nM | 6.94 |
| CHEMBL128184 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL2111848 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL338095 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL125417 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL126823 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL338696 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL126994 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL125361 | — | Ki | = | 185.0 | nM | 6.73 |
| CHEMBL126897 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL126737 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL338081 | — | Ki | = | 225.0 | nM | 6.65 |
| CHEMBL130585 | — | Ki | = | 280.0 | nM | 6.55 |
| CHEMBL435814 | — | Ki | = | 285.0 | nM | 6.54 |
| CHEMBL128945 | — | Ki | = | 415.0 | nM | 6.38 |
| CHEMBL340511 | — | Ki | = | 480.0 | nM | 6.32 |
| CHEMBL126188 | — | Ki | = | 625.0 | nM | 6.20 |
| CHEMBL92879 | — | Ki | = | 3100.0 | nM | 5.51 |