Assay Detail
Binding
CHEMBL618896
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Binding affinity was measured against 5-hydroxytryptamine 2A receptor by displacement of [3H]- ketanserin by lysergic acid amides
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Stereoselective LSD-like activity in a series of d-lysergic acid amides of (R)- and (S)-2-aminoalkanes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 7.66 | 8.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | 2.0 | 1 | 8.36 |
| CHEMBL369829 | — | — | 1 | 8.35 |
| CHEMBL424777 | — | — | 1 | 8.10 |
| CHEMBL66335 | — | — | 1 | 8.06 |
| CHEMBL422732 | — | — | 1 | 7.80 |
| CHEMBL177034 | — | — | 1 | 7.47 |
| CHEMBL172369 | — | — | 1 | 7.26 |
| CHEMBL176343 | — | — | 1 | 7.10 |
| CHEMBL172947 | — | — | 1 | 6.45 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL263881 | LYSERGIDE | Ki | = | 4.4 | nM | 8.36 |
| CHEMBL369829 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL424777 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL66335 | — | Ki | = | 8.8 | nM | 8.06 |
| CHEMBL422732 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL177034 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL172369 | — | Ki | = | 55.0 | nM | 7.26 |
| CHEMBL176343 | — | Ki | = | 80.0 | nM | 7.10 |
| CHEMBL172947 | — | Ki | = | 357.0 | nM | 6.45 |