Assay Detail
Binding
CHEMBL618897
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was evaluated for affinity towards cerebral 5-hydroxytryptamine 2A receptor in homogenate of caudate putamen tissue from rat brain
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Caudate-putamen |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Cyclopentadienyltricarbonylrheniumbenzazepines: synthesis and binding affinity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.62 | 8.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13632 | — | — | 1 | 8.07 |
| CHEMBL62 | SCH-23390 | — | 1 | 7.97 |
| CHEMBL274577 | Cyclopentadienyltricarbonylrheniumbenzazepine (2`-CPTR-SCH-23390) | — | 1 | 7.76 |
| CHEMBL13325 | — | — | 1 | 7.66 |
| CHEMBL427996 | Cyclopentadienyltricarbonylrheniumbenzazepine (3`-CPTR-SCH-23390) | — | 1 | 6.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13632 | — | Ki | = | 8.5 | nM | 8.07 |
| CHEMBL62 | SCH-23390 | Ki | = | 10.8 | nM | 7.97 |
| CHEMBL274577 | Cyclopentadienyltricarbonylrheniumbenzazepine (2`-CPTR-SCH-23390) | Ki | = | 17.3 | nM | 7.76 |
| CHEMBL13325 | — | Ki | = | 22.1 | nM | 7.66 |
| CHEMBL427996 | Cyclopentadienyltricarbonylrheniumbenzazepine (3`-CPTR-SCH-23390) | Ki | = | 227.0 | nM | 6.64 |