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Assay Detail

CHEMBL619176

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at rat 5-hydroxytryptamine receptor.
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Serotonin (5-HT) receptor (CHEMBL2094123)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Behavioral and serotonin receptor properties of 4-substituted derivatives of the hallucinogen 1-(2,5-dimethoxyphenyl)-2-aminopropane.
Glennon RA, Young R, Benington F, Morin RD.
J Med Chem (1982) 25 : 1163 -1168
PubMed 7143352 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 17 6.66 7.63

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL134519 1 7.63
CHEMBL1788278 1 7.49
CHEMBL6616 1 7.49
CHEMBL6607 BROLAMFETAMINE 2.0 1 7.35
CHEMBL267526 1 7.20
CHEMBL8224 1 7.18
CHEMBL8600 DOM 1 7.13
CHEMBL8301 1 7.07
CHEMBL468880 1 6.93
CHEMBL8642 1 6.83
CHEMBL8389 1 6.81
CHEMBL8225 1 6.78
CHEMBL16247 1 5.93
CHEMBL16451 1 5.54
CHEMBL2079629 1 5.38
CHEMBL16883 1 5.27
CHEMBL278663 PARA-METHOXYAMPHETAMINE 1 5.15

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL134519 Kd = 23.44 nM 7.63
CHEMBL1788278 Kd = 32.36 nM 7.49
CHEMBL6616 Kd = 32.36 nM 7.49
CHEMBL6607 BROLAMFETAMINE Kd = 44.67 nM 7.35
CHEMBL267526 Kd = 63.1 nM 7.20
CHEMBL8224 Kd = 66.07 nM 7.18
CHEMBL8600 DOM Kd = 74.13 nM 7.13
CHEMBL8301 Kd = 85.11 nM 7.07
CHEMBL468880 Kd = 117.49 nM 6.93
CHEMBL8642 Kd = 147.91 nM 6.83
CHEMBL8389 Kd = 154.88 nM 6.81
CHEMBL8225 Kd = 165.96 nM 6.78
CHEMBL16247 Kd = 1174.9 nM 5.93
CHEMBL16451 Kd = 2884.03 nM 5.54
CHEMBL2079629 Kd = 4168.69 nM 5.38
CHEMBL16883 Kd = 5370.32 nM 5.27
CHEMBL278663 PARA-METHOXYAMPHETAMINE Kd = 7079.46 nM 5.15