Assay Detail
Binding
CHEMBL619183
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Compound was evaluated for binding affinity towards 5-hydroxytryptamine receptor in isolated rat fundus preparation measured as pA2
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Studies on several 7-substituted N,N-dimethyltryptamines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 8 | 6.14 | 6.61 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL20243 | — | — | 1 | 6.61 |
| CHEMBL21083 | — | — | 1 | 6.51 |
| CHEMBL20971 | — | — | 1 | 6.31 |
| CHEMBL20167 | — | — | 1 | 6.29 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | 2.0 | 1 | 6.00 |
| CHEMBL13573 | — | — | 1 | 5.98 |
| CHEMBL16247 | — | — | 1 | 5.93 |
| CHEMBL20137 | — | — | 1 | 5.50 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL20243 | — | Kd | = | 245.47 | nM | 6.61 |
| CHEMBL21083 | — | Kd | = | 309.03 | nM | 6.51 |
| CHEMBL20971 | — | Kd | = | 489.78 | nM | 6.31 |
| CHEMBL20167 | — | Kd | = | 512.86 | nM | 6.29 |
| CHEMBL12420 | N,N-DIMETHYLTRYPTAMINE | Kd | = | 1000.0 | nM | 6.00 |
| CHEMBL13573 | — | Kd | = | 1047.13 | nM | 5.98 |
| CHEMBL16247 | — | Kd | = | 1174.9 | nM | 5.93 |
| CHEMBL20137 | — | Kd | = | 3162.28 | nM | 5.50 |