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Compound Detail

CHEMBL20971

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CCc1cccc2c(CCN(C)C)c[nH]c12

Basic Information

ChEMBL ID CHEMBL20971
Phase Preclinical
Structure Type MOL
InChI Key DNEWEHQANHHHCZ-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

216.3
MW (Da)
2.83
ALogP
1
HBA
1
HBD
19.0
PSA (Ų)
0.83
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C14H20N2
MW 216.33
Aromatic Rings 2
Heavy Atoms 16
NP-Likeness -0.44

Activity Summary

Kd 1 meas. best 6.31

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serotonin (5-HT) receptor
CHEMBL2094123
Kd 6.31 6.31 489.8 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
6779006 10.1021/jm00185a014 Serotonin (5-HT) receptor 1

Data from ChEMBL 36 via Core Engine