Assay Detail
Binding
CHEMBL619225
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against 5-lipoxygenase obtained from rat basophilic leukemia cells
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.51 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL59356 | ATRELEUTON | 2.0 | 1 | 7.64 |
| CHEMBL132859 | — | — | 1 | 6.80 |
| CHEMBL135483 | — | — | 1 | 6.52 |
| CHEMBL135986 | — | — | 1 | 6.52 |
| CHEMBL93 | ZILEUTON | 4.0 | 1 | 6.30 |
| CHEMBL274642 | BW-755C | — | 1 | 5.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL59356 | ATRELEUTON | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL132859 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL135483 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL135986 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL93 | ZILEUTON | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL274642 | BW-755C | IC50 | = | 5600.0 | nM | 5.25 |