Compound Detail
CHEMBL135483
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL135483 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HBWJNIFURYPZMX-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
294.3
MW (Da)
3.22
ALogP
4
HBA
2
HBD
66.8
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL312 | IC50 | 6.52 | 6.52 | 300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 300.0 | nM | 6.52 | Inhibitory activity against 5-lipoxygenase obtained from rat basophilic leukemia... | 9484493 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 9484493 | 10.1021/jm970034q | Polyunsaturated fatty acid 5-lipoxygenase | 2 |
| 9484493 | 10.1021/jm970034q | Prostaglandin G/H synthase 1 | 1 |
| 9484493 | 10.1021/jm970034q | Prostaglandin G/H synthase 2 | 1 |
| 9484493 | 10.1021/jm970034q | Cavia porcellus | 1 |
Data from ChEMBL 36 via Core Engine