Assay Detail
Functional
CHEMBL619465
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Concentration required to inhibit A2780-cell growth by 50%
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
1,4- and 2,6-disubstituted amidoanthracene-9,10-dione derivatives as inhibitors of human telomerase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.15 | 9.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | 4.0 | 1 | 9.26 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 8.02 |
| CHEMBL545043 | — | — | 1 | 7.80 |
| CHEMBL544805 | — | — | 1 | 7.70 |
| CHEMBL544572 | — | — | 1 | 6.89 |
| CHEMBL545044 | — | — | 1 | 6.54 |
| CHEMBL322686 | — | — | 1 | 6.42 |
| CHEMBL111785 | — | — | 1 | 6.42 |
| CHEMBL109403 | — | — | 1 | 6.30 |
| CHEMBL322704 | — | — | 1 | 6.12 |
| CHEMBL109542 | — | — | 1 | 5.90 |
| CHEMBL109382 | — | — | 1 | 5.89 |
| CHEMBL110592 | — | — | 1 | 5.85 |
| CHEMBL419381 | — | — | 1 | 5.78 |
| CHEMBL109890 | — | — | 1 | 5.76 |
| CHEMBL110044 | — | — | 1 | 5.72 |
| CHEMBL111417 | — | — | 1 | 5.67 |
| CHEMBL109617 | — | — | 1 | 5.65 |
| CHEMBL111791 | — | — | 1 | 5.61 |
| CHEMBL111164 | — | — | 1 | 5.59 |
| CHEMBL544111 | — | — | 1 | 5.43 |
| CHEMBL109388 | — | — | 1 | 5.32 |
| CHEMBL111206 | — | — | 1 | 5.23 |
| CHEMBL109046 | — | — | 1 | 5.19 |
| CHEMBL323448 | — | — | 1 | 4.96 |
| CHEMBL108747 | — | — | 1 | 4.89 |
| CHEMBL107707 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL58 | MITOXANTRONE | IC50 | = | 0.55 | nM | 9.26 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 9.6 | nM | 8.02 |
| CHEMBL545043 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL544805 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL544572 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL545044 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL322686 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL111785 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL109403 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL322704 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL109542 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL109382 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL110592 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL419381 | — | IC50 | = | 1650.0 | nM | 5.78 |
| CHEMBL109890 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL110044 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL111417 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL109617 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL111791 | — | IC50 | = | 2450.0 | nM | 5.61 |
| CHEMBL111164 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL544111 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL109388 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL111206 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL109046 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL323448 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL108747 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL107707 | — | IC50 | < | 1000.0 | nM | - |