Assay Detail
Binding
CHEMBL619913
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Inhibition of rat basophilic leukemia cell 5-lipoxygenase
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Antiinflammatory -benzeneethanamines. III
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.78 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274642 | BW-755C | — | 1 | 6.00 |
| CHEMBL545590 | — | — | 1 | 5.02 |
| CHEMBL535346 | — | — | 1 | 4.64 |
| CHEMBL536933 | — | — | 1 | 4.46 |
| CHEMBL539068 | — | — | 2 | 4.42 |
| CHEMBL542998 | — | — | 1 | - |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | - |
| CHEMBL384467 | DEXAMETHASONE | 4.0 | 1 | - |
| CHEMBL7568 | QUINACRINE | 4.0 | 1 | - |
| CHEMBL558583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274642 | BW-755C | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL545590 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL535346 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL536933 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL539068 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL539068 | — | IC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL542998 | — | IC50 | = | 130000.0 | nM | - |
| CHEMBL6 | INDOMETHACIN | IC50 | > | 250000.0 | nM | - |
| CHEMBL384467 | DEXAMETHASONE | IC50 | > | 25000.0 | nM | - |
| CHEMBL7568 | QUINACRINE | IC50 | = | 130000.0 | nM | - |
| CHEMBL558583 | — | IC50 | = | 230000.0 | nM | - |