Assay Detail
Functional
CHEMBL619983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antitumor activity of compound against 7404 cell line (human liver carcinoma cells)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BEL-7404 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of OSW-1 analogs with modified side chains and their antitumor activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.34 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL443535 | — | — | 1 | 7.50 |
| CHEMBL327536 | — | — | 1 | 7.20 |
| CHEMBL262508 | — | — | 1 | 7.00 |
| CHEMBL92531 | — | — | 1 | 5.73 |
| CHEMBL96545 | — | — | 1 | 5.54 |
| CHEMBL11359 | CISPLATIN | 4.0 | 1 | 5.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL443535 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL327536 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL262508 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL92531 | — | IC50 | = | 1860.0 | nM | 5.73 |
| CHEMBL96545 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL11359 | CISPLATIN | IC50 | = | 8370.0 | nM | 5.08 |