Assay Detail
Binding
CHEMBL619984
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In vitro inhibition of 5-lipoxygenase activity in RBL-1 cells.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | RBL-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Structural analysis of 2-aryl-1,3-dione compounds as inhibitors of 5-lipoxygenase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.27 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25994 | — | — | 1 | 5.77 |
| CHEMBL24960 | — | — | 1 | 5.77 |
| CHEMBL7660 | PHENIDONE | — | 1 | 5.72 |
| CHEMBL24295 | — | — | 1 | 5.70 |
| CHEMBL282432 | — | — | 1 | 5.64 |
| CHEMBL25319 | — | — | 1 | 5.57 |
| CHEMBL277203 | — | — | 1 | 5.55 |
| CHEMBL282063 | — | — | 1 | 5.50 |
| CHEMBL24298 | — | — | 1 | 5.35 |
| CHEMBL25248 | — | — | 1 | 5.32 |
| CHEMBL278519 | CLORINDIONE | 2.0 | 1 | 5.30 |
| CHEMBL712 | ANISINDIONE | 4.0 | 1 | 5.04 |
| CHEMBL24924 | FLUINDIONE | 2.0 | 1 | 5.02 |
| CHEMBL278803 | — | — | 1 | 4.92 |
| CHEMBL711 | PHENINDIONE | 4.0 | 1 | 4.82 |
| CHEMBL278362 | — | — | 1 | 4.82 |
| CHEMBL279426 | — | — | 1 | 4.60 |
| CHEMBL279427 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25994 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL24960 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL7660 | PHENIDONE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL24295 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL282432 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL25319 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL277203 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL282063 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL24298 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL25248 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL278519 | CLORINDIONE | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL712 | ANISINDIONE | IC50 | = | 9100.0 | nM | 5.04 |
| CHEMBL24924 | FLUINDIONE | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL278803 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL711 | PHENINDIONE | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL278362 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL279426 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL279427 | — | IC50 | = | 41000.0 | nM | 4.39 |