Compound Detail
CHEMBL278519
CLORINDIONE 🧪 Phase II
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🧪 Phase II
Basic Information
| ChEMBL ID | CHEMBL278519 |
| Name | CLORINDIONE |
| Phase | Phase II |
| Structure Type | MOL |
| InChI Key | NJDUWAXIURWWLN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
8
Publications
5
Known Names
1
Indications
Molecular Properties
256.7
MW (Da)
3.50
ALogP
2
HBA
0
HBD
34.1
PSA (Ų)
0.73
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Chirality | Achiral |
Indications
Thrombosis
ATC Classification
B01AA09
clorindione
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: ANTITHROMBOTIC AGENTS
Activity Summary
IC50 1 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase CHEMBL312 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Polyunsaturated fatty acid 5-lipoxygenase | IC50 | = | 5000.0 | nM | 5.3 | In vitro inhibition of 5-lipoxygenase activity in RBL-1 cells. | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 4067989 | 10.1021/jm00149a008 | Mus musculus | 3 |
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4651402 | SARS-CoV-2 | 2 |
| - | 10.6019/CHEMBL4808148 | Histone deacetylase 6 | 2 |
| - | 10.1016/S0960-894X(00)80236-X | Polyunsaturated fatty acid 5-lipoxygenase | 1 |
| 321782 | 10.1021/jm00214a001 | Molecular identity unknown | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine