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Assay Detail

CHEMBL620717

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards human 5-hydroxytryptamine 5A receptor using LSD as radioligand
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 5A (CHEMBL3426)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Binding of tetrahydrocarboline derivatives at human 5-HT5A receptors.
Khorana N, Smith C, Herrick-Davis K, Purohit A, Teitler M, Grella B, Dukat M, Glennon RA.
J Med Chem (2003) 46 : 3930 -3937
PubMed 12930153 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 22 6.55 7.26

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL96504 1 7.26
CHEMBL128099 1 7.00
CHEMBL128848 1 7.00
CHEMBL128185 1 6.78
CHEMBL129476 1 6.78
CHEMBL125417 1 6.76
CHEMBL446356 1 6.73
CHEMBL435814 1 6.72
CHEMBL126897 1 6.70
CHEMBL126898 1 6.70
CHEMBL2111848 1 6.68
CHEMBL126737 1 6.65
CHEMBL130585 1 6.60
CHEMBL338095 1 6.57
CHEMBL338696 1 6.54
CHEMBL126138 1 6.47
CHEMBL340646 1 6.46
CHEMBL126823 1 6.21
CHEMBL126994 1 6.03
CHEMBL126021 1 5.95
CHEMBL128184 1 5.86
CHEMBL129774 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL96504 Ki = 55.0 nM 7.26
CHEMBL128099 Ki = 100.0 nM 7.00
CHEMBL128848 Ki = 100.0 nM 7.00
CHEMBL128185 Ki = 165.0 nM 6.78
CHEMBL129476 Ki = 168.0 nM 6.78
CHEMBL125417 Ki = 174.0 nM 6.76
CHEMBL446356 Ki = 185.0 nM 6.73
CHEMBL435814 Ki = 190.0 nM 6.72
CHEMBL126897 Ki = 200.0 nM 6.70
CHEMBL126898 Ki = 200.0 nM 6.70
CHEMBL2111848 Ki = 208.0 nM 6.68
CHEMBL126737 Ki = 225.0 nM 6.65
CHEMBL130585 Ki = 250.0 nM 6.60
CHEMBL338095 Ki = 270.0 nM 6.57
CHEMBL338696 Ki = 285.0 nM 6.54
CHEMBL126138 Ki = 340.0 nM 6.47
CHEMBL340646 Ki = 350.0 nM 6.46
CHEMBL126823 Ki = 620.0 nM 6.21
CHEMBL126994 Ki = 930.0 nM 6.03
CHEMBL126021 Ki = 1120.0 nM 5.95
CHEMBL128184 Ki = 1395.0 nM 5.86
CHEMBL129774 Ki = 1775.0 nM 5.75