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Assay Detail

CHEMBL620766

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity at rat 5-hydroxytryptamine 7 receptor.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 7 (CHEMBL3223)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

Characterization of the 5-HT(7) receptor. Determination of the pharmacophore for 5-HT(7) receptor agonism and CoMFA-based modeling of the agonist binding site.
Vermeulen ES, Schmidt AW, Sprouse JS, Wikström HV, Grol CJ.
J Med Chem (2003) 46 : 5365 -5374
PubMed 14640545 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 20 7.68 9.92

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL18840 1 9.92
CHEMBL611472 1 9.60
CHEMBL39 SEROTONIN 3.0 1 9.22
CHEMBL609675 1 9.08
CHEMBL8165 5-METHOXYTRYPTAMINE 1 9.03
CHEMBL416526 BUFOTENINE 1 8.10
CHEMBL263881 LYSERGIDE 2.0 1 8.02
CHEMBL92221 1 7.79
CHEMBL277120 1 7.74
CHEMBL300824 1 7.69
CHEMBL90053 1 7.47
CHEMBL7257 MEBUFOTENIN 2.0 1 7.40
CHEMBL26998 1 7.34
CHEMBL608536 1 7.06
CHEMBL1161324 1 6.91
CHEMBL9666 1 6.90
CHEMBL315684 1 6.47
CHEMBL608537 1 6.20
CHEMBL7143 1 5.95
CHEMBL1161325 1 5.80

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL18840 Ki = 0.1202 nM 9.92
CHEMBL611472 Ki = 0.2512 nM 9.60
CHEMBL39 SEROTONIN Ki = 0.6026 nM 9.22
CHEMBL609675 Ki = 0.8318 nM 9.08
CHEMBL8165 5-METHOXYTRYPTAMINE Ki = 0.9333 nM 9.03
CHEMBL416526 BUFOTENINE Ki = 7.943 nM 8.10
CHEMBL263881 LYSERGIDE Ki = 9.55 nM 8.02
CHEMBL92221 Ki = 16.22 nM 7.79
CHEMBL277120 Ki = 18.2 nM 7.74
CHEMBL300824 Ki = 20.42 nM 7.69
CHEMBL90053 Ki = 33.88 nM 7.47
CHEMBL7257 MEBUFOTENIN Ki = 39.81 nM 7.40
CHEMBL26998 Ki = 45.71 nM 7.34
CHEMBL608536 Ki = 87.1 nM 7.06
CHEMBL1161324 Ki = 123.03 nM 6.91
CHEMBL9666 Ki = 125.89 nM 6.90
CHEMBL315684 Ki = 338.84 nM 6.47
CHEMBL608537 Ki = 630.96 nM 6.20
CHEMBL7143 Ki = 1122.02 nM 5.95
CHEMBL1161325 Ki = 1584.89 nM 5.80