Assay Detail
Functional
CHEMBL621014
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In vitro cytotoxicity against A2780TAX cell line
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis and biological evaluation of 2'-methyl taxoids derived from baccatin III and 14beta-OH-baccatin III 1,14-carbonate.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.58 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144191 | — | — | 1 | 7.51 |
| CHEMBL382300 | ORTATAXEL | 2.0 | 1 | 7.25 |
| CHEMBL358369 | — | — | 1 | 6.54 |
| CHEMBL341623 | — | — | 1 | 6.52 |
| CHEMBL357427 | — | — | 1 | 6.51 |
| CHEMBL356139 | — | — | 1 | 6.38 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144191 | — | IC50 | = | 30.9 | nM | 7.51 |
| CHEMBL382300 | ORTATAXEL | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL358369 | — | IC50 | = | 285.0 | nM | 6.54 |
| CHEMBL341623 | — | IC50 | = | 299.0 | nM | 6.52 |
| CHEMBL357427 | — | IC50 | = | 312.0 | nM | 6.51 |
| CHEMBL356139 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 4498.0 | nM | 5.35 |