Assay Detail
Functional
CHEMBL621024
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of epidermal growth factor receptor (EGF-R) autophosphorylation in A431 cells
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A-431 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
A novel series of 4-phenoxyquinolines: potent and highly selective inhibitors of PDGF receptor autophosphorylation
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.21 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29197 | — | — | 1 | 8.40 |
| CHEMBL98798 | — | — | 1 | 7.16 |
| CHEMBL98248 | — | — | 1 | 6.43 |
| CHEMBL101581 | — | — | 1 | 5.60 |
| CHEMBL100714 | — | — | 1 | 5.55 |
| CHEMBL98137 | — | — | 1 | 4.09 |
| CHEMBL431818 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29197 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL98798 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL98248 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL101581 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL100714 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL98137 | — | IC50 | = | 80500.0 | nM | 4.09 |
| CHEMBL431818 | — | IC50 | > | 100000.0 | nM | - |