Assay Detail
Binding
CHEMBL621546
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Binding affinity towards rat cortical 5-hydroxytryptamine 2A receptor using [3H]ketanserin as radioligand
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Dihydrobenzofuran analogues of hallucinogens. 3. Models of 4-substituted (2,5-dimethoxyphenyl)alkylamine derivatives with rigidified methoxy groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.84 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL101008 | — | — | 1 | 7.75 |
| CHEMBL6607 | BROLAMFETAMINE | 2.0 | 1 | 7.66 |
| CHEMBL101189 | — | — | 1 | 7.47 |
| CHEMBL99846 | — | — | 1 | 5.70 |
| CHEMBL100626 | — | — | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL101008 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL6607 | BROLAMFETAMINE | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL101189 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL99846 | — | Ki | = | 2010.0 | nM | 5.70 |
| CHEMBL100626 | — | Ki | = | 2300.0 | nM | 5.64 |