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Assay Detail

CHEMBL622413

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro cytotoxicity against human ovarian carcinoma cell line A2780 using sulforhodamine B (SRB) assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A2780
Confidence 1 — Organism
Curated By Expert

Target

A2780 (CHEMBL614004)
Type CELL-LINE
Organism Homo sapiens

Publication

Human telomerase inhibition by substituted acridine derivatives.
Harrison RJ, Gowan SM, Kelland LR, Neidle S.
Bioorg Med Chem Lett (1999) 9 : 2463 -2468
PubMed 10498189 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 5.81 6.51

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL310569 1 6.51
CHEMBL79536 1 6.30
CHEMBL309982 1 6.24
CHEMBL311072 1 6.12
CHEMBL82008 1 5.96
CHEMBL310838 1 5.89
CHEMBL81268 1 5.77
CHEMBL431404 1 5.76
CHEMBL83173 1 5.68
CHEMBL309919 1 5.67
CHEMBL81747 1 5.66
CHEMBL81271 1 5.64
CHEMBL79900 1 5.58
CHEMBL421143 1 5.51
CHEMBL311055 1 5.50
CHEMBL81516 1 5.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL310569 IC50 = 310.0 nM 6.51
CHEMBL79536 IC50 = 500.0 nM 6.30
CHEMBL309982 IC50 = 570.0 nM 6.24
CHEMBL311072 IC50 = 750.0 nM 6.12
CHEMBL82008 IC50 = 1100.0 nM 5.96
CHEMBL310838 IC50 = 1300.0 nM 5.89
CHEMBL81268 IC50 = 1700.0 nM 5.77
CHEMBL431404 IC50 = 1750.0 nM 5.76
CHEMBL83173 IC50 = 2100.0 nM 5.68
CHEMBL309919 IC50 = 2150.0 nM 5.67
CHEMBL81747 IC50 = 2200.0 nM 5.66
CHEMBL81271 IC50 = 2300.0 nM 5.64
CHEMBL79900 IC50 = 2650.0 nM 5.58
CHEMBL421143 IC50 = 3100.0 nM 5.51
CHEMBL311055 IC50 = 3200.0 nM 5.50
CHEMBL81516 IC50 = 6200.0 nM 5.21