Assay Detail
Functional
CHEMBL622591
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Antiproliferative activity against human A2780 cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.14 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL115933 | — | — | 1 | 6.96 |
| CHEMBL114636 | — | — | 1 | 6.92 |
| CHEMBL114718 | — | — | 1 | 6.74 |
| CHEMBL114790 | — | — | 1 | 6.69 |
| CHEMBL115220 | — | — | 1 | 6.54 |
| CHEMBL326501 | — | — | 1 | 6.05 |
| CHEMBL114851 | — | — | 1 | 5.85 |
| CHEMBL112433 | — | — | 1 | 5.83 |
| CHEMBL324577 | — | — | 1 | 5.55 |
| CHEMBL115994 | — | — | 1 | 5.30 |
| CHEMBL323821 | — | — | 1 | 5.16 |
| CHEMBL114917 | — | — | 1 | - |
| CHEMBL114156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL115933 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL114636 | — | IC50 | = | 121.0 | nM | 6.92 |
| CHEMBL114718 | — | IC50 | = | 182.0 | nM | 6.74 |
| CHEMBL114790 | — | IC50 | = | 205.0 | nM | 6.69 |
| CHEMBL115220 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL326501 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL114851 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL112433 | — | IC50 | = | 1468.0 | nM | 5.83 |
| CHEMBL324577 | — | IC50 | = | 2835.0 | nM | 5.55 |
| CHEMBL115994 | — | IC50 | = | 4990.0 | nM | 5.30 |
| CHEMBL323821 | — | IC50 | = | 6984.0 | nM | 5.16 |
| CHEMBL114917 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL114156 | — | IC50 | > | 20000.0 | nM | - |