Assay Detail
Functional
CHEMBL622593
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative effect against human A2780 cell line was determined in a whole cell 72 hr cytotoxicity assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.75 | 7.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL300936 | — | — | 1 | 7.54 |
| CHEMBL297755 | — | — | 1 | 7.54 |
| CHEMBL49618 | — | — | 1 | 7.31 |
| CHEMBL295136 | — | — | 1 | 7.30 |
| CHEMBL428690 | ALVOCIDIB | 3.0 | 1 | 7.15 |
| CHEMBL301316 | — | — | 1 | 7.11 |
| CHEMBL296468 | BMS-387032 | 1.0 | 1 | 7.02 |
| CHEMBL45860 | — | — | 1 | 7.00 |
| CHEMBL45757 | — | — | 1 | 6.96 |
| CHEMBL49814 | — | — | 1 | 6.92 |
| CHEMBL297570 | — | — | 1 | 6.75 |
| CHEMBL47116 | — | — | 1 | 6.75 |
| CHEMBL301184 | — | — | 1 | 6.28 |
| CHEMBL48796 | — | — | 1 | 6.08 |
| CHEMBL46164 | — | — | 1 | 5.80 |
| CHEMBL295835 | — | — | 1 | 5.75 |
| CHEMBL295918 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL300936 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL297755 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL49618 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL295136 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL428690 | ALVOCIDIB | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL301316 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL296468 | BMS-387032 | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL45860 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL45757 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL49814 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL297570 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL47116 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL301184 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL48796 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL46164 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL295835 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL295918 | — | IC50 | = | 2900.0 | nM | 5.54 |