Assay Detail
Functional
CHEMBL622595
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Cell cytotoxicity was determined against human ovarian cancer (A2780) cell line
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis, DNA-damaging and cytotoxic properties of novel topoisomerase II-directed bisantrene analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.33 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL25336 | BISANTRENE | 3.0 | 1 | 6.47 |
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 6.46 |
| CHEMBL22696 | — | — | 1 | 5.32 |
| CHEMBL417829 | — | — | 1 | 4.73 |
| CHEMBL278341 | — | — | 1 | 4.55 |
| CHEMBL276966 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL25336 | BISANTRENE | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL43 | AMSACRINE | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL22696 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL417829 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL278341 | — | IC50 | = | 28100.0 | nM | 4.55 |
| CHEMBL276966 | — | IC50 | = | 37800.0 | nM | 4.42 |