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Assay Detail

CHEMBL622597

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Growth inhibition against A2780 wild-type ovarian cell lines
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type A2780
Confidence 1 — Organism
Curated By Expert

Target

A2780 (CHEMBL614004)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of novel chloroethylaminoanthraquinones with potent cytotoxic activity against cisplatin-resistant tumor cells.
Pors K, Paniwnyk Z, Ruparelia KC, Teesdale-Spittle PH, Hartley JA, Kelland LR, Patterson LH.
J Med Chem (2004) 47 : 1856 -1859
PubMed 15027879 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 20 6.76 8.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53843 1 8.40
CHEMBL55845 1 8.30
CHEMBL300531 1 8.05
CHEMBL53164 1 7.89
CHEMBL55820 1 7.80
CHEMBL57109 1 7.55
CHEMBL293516 1 7.51
CHEMBL55064 1 7.29
CHEMBL55955 1 7.09
CHEMBL417917 1 6.92
CHEMBL53117 1 6.87
CHEMBL51686 1 6.39
CHEMBL52667 1 6.17
CHEMBL52364 1 6.14
CHEMBL55016 1 5.57
CHEMBL51757 1 5.51
CHEMBL418094 1 5.48
CHEMBL296381 1 5.47
CHEMBL54868 1 5.46
CHEMBL51751 1 5.34

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53843 IC50 = 4.0 nM 8.40
CHEMBL55845 IC50 = 5.0 nM 8.30
CHEMBL300531 IC50 = 9.0 nM 8.05
CHEMBL53164 IC50 = 13.0 nM 7.89
CHEMBL55820 IC50 = 16.0 nM 7.80
CHEMBL57109 IC50 = 28.0 nM 7.55
CHEMBL293516 IC50 = 31.0 nM 7.51
CHEMBL55064 IC50 = 51.0 nM 7.29
CHEMBL55955 IC50 = 82.0 nM 7.09
CHEMBL417917 IC50 = 120.0 nM 6.92
CHEMBL53117 IC50 = 135.0 nM 6.87
CHEMBL51686 IC50 = 410.0 nM 6.39
CHEMBL52667 IC50 = 680.0 nM 6.17
CHEMBL52364 IC50 = 720.0 nM 6.14
CHEMBL55016 IC50 = 2700.0 nM 5.57
CHEMBL51757 IC50 = 3100.0 nM 5.51
CHEMBL418094 IC50 = 3300.0 nM 5.48
CHEMBL296381 IC50 = 3400.0 nM 5.47
CHEMBL54868 IC50 = 3500.0 nM 5.46
CHEMBL51751 IC50 = 4600.0 nM 5.34