Assay Detail
Functional
CHEMBL622692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dose of required to inhibit growth of cisplatin resistant human ovarian carcinoma (A2780 cisR) cell line with compound free controls as measured by the sulforhodamine B growth delay assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.18 | 10.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL16498 | SJG-136 | 2.0 | 1 | 10.62 |
| CHEMBL319087 | — | — | 1 | 7.24 |
| CHEMBL279754 | DSB-120 | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL16498 | SJG-136 | IC50 | = | 0.024 | nM | 10.62 |
| CHEMBL319087 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL279754 | DSB-120 | IC50 | = | 210.0 | nM | 6.68 |