Assay Detail
Functional
CHEMBL624511
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro cytotoxicity against A2780 ovarian cells using the sulforhodamine B(SRB) assay.
50
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A2780 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Human telomerase inhibition by regioisomeric disubstituted amidoanthracene-9,10-diones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 50 | 6.11 | 8.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL345004 | — | — | 1 | 8.60 |
| CHEMBL300584 | — | — | 1 | 7.80 |
| CHEMBL14832 | — | — | 1 | 6.75 |
| CHEMBL141831 | — | — | 1 | 6.70 |
| CHEMBL359443 | — | — | 1 | 6.54 |
| CHEMBL444340 | — | — | 1 | 6.53 |
| CHEMBL144664 | — | — | 1 | 6.50 |
| CHEMBL144088 | — | — | 1 | 6.50 |
| CHEMBL423017 | — | — | 1 | 6.48 |
| CHEMBL144984 | — | — | 1 | 6.48 |
| CHEMBL356077 | — | — | 1 | 6.46 |
| CHEMBL144848 | — | — | 1 | 6.36 |
| CHEMBL144756 | — | — | 1 | 6.36 |
| CHEMBL89250 | — | — | 1 | 6.32 |
| CHEMBL146602 | — | — | 1 | 6.32 |
| CHEMBL144617 | — | — | 1 | 6.29 |
| CHEMBL144999 | — | — | 1 | 6.28 |
| CHEMBL422120 | — | — | 1 | 6.28 |
| CHEMBL343238 | — | — | 1 | 6.28 |
| CHEMBL144386 | — | — | 1 | 6.27 |
| CHEMBL145311 | — | — | 1 | 6.26 |
| CHEMBL144134 | — | — | 1 | 6.25 |
| CHEMBL144219 | — | — | 1 | 6.22 |
| CHEMBL145575 | — | — | 1 | 6.19 |
| CHEMBL322704 | — | — | 1 | 6.12 |
| CHEMBL144757 | — | — | 1 | 5.92 |
| CHEMBL33618 | — | — | 1 | 5.89 |
| CHEMBL143452 | — | — | 1 | 5.82 |
| CHEMBL145490 | — | — | 1 | 5.77 |
| CHEMBL109890 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL345004 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL300584 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL14832 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL141831 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL359443 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL444340 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL144664 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL144088 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL423017 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL144984 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL356077 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL144848 | — | IC50 | = | 435.0 | nM | 6.36 |
| CHEMBL144756 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL146602 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL89250 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL144617 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL144999 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL422120 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL343238 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL144386 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL145311 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL144134 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL144219 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL145575 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL322704 | — | IC50 | = | 760.0 | nM | 6.12 |
| CHEMBL144757 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL33618 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL143452 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL145490 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL109890 | — | IC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL142900 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL110044 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL344274 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL144334 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL146111 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL89977 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL91163 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL111417 | — | IC50 | = | 2150.0 | nM | 5.67 |
| CHEMBL344072 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL109617 | — | IC50 | = | 2250.0 | nM | 5.65 |
| CHEMBL34683 | — | IC50 | = | 2350.0 | nM | 5.63 |
| CHEMBL444347 | — | IC50 | = | 2550.0 | nM | 5.59 |
| CHEMBL144827 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL144303 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL91898 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL343445 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL144208 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL144411 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL107707 | — | IC50 | < | 1000.0 | nM | - |
| CHEMBL33505 | — | IC50 | > | 25000.0 | nM | - |