Assay Detail
ADMET
CHEMBL633438
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Tested for antimuscarinic potency on guinea pig heart force
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cavia porcellus |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enantioselectivity of muscarinic antagonists. Isomeric 2-cyclohexyl-2-phenyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 8.01 | 8.95 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.95 |
| CHEMBL45454 | — | — | 3 | 8.47 |
| CHEMBL45452 | — | — | 3 | 8.11 |
| CHEMBL45125 | — | — | 1 | 7.48 |
| CHEMBL40559 | — | — | 1 | 6.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Kd | = | 1.122 | nM | 8.95 |
| CHEMBL45454 | — | Kd | = | 3.388 | nM | 8.47 |
| CHEMBL45454 | — | Kd | = | 6.918 | nM | 8.16 |
| CHEMBL45454 | — | Kd | = | 7.413 | nM | 8.13 |
| CHEMBL45452 | — | Kd | = | 7.762 | nM | 8.11 |
| CHEMBL45452 | — | Kd | = | 7.943 | nM | 8.10 |
| CHEMBL45452 | — | Kd | = | 8.511 | nM | 8.07 |
| CHEMBL45125 | — | Kd | = | 33.11 | nM | 7.48 |
| CHEMBL40559 | — | Kd | = | 263.03 | nM | 6.58 |