Assay Detail
ADMET
CHEMBL633439
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Tested for antimuscarinic potency on guinea pig heart rate
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cavia porcellus |
| Tissue | Heart |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enantioselectivity of muscarinic antagonists. Isomeric 2-cyclohexyl-2-phenyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 7.97 | 9.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.05 |
| CHEMBL45454 | — | — | 3 | 8.35 |
| CHEMBL45452 | — | — | 3 | 8.14 |
| CHEMBL45125 | — | — | 1 | 7.43 |
| CHEMBL40559 | — | — | 1 | 6.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Kd | = | 0.8913 | nM | 9.05 |
| CHEMBL45454 | — | Kd | = | 4.467 | nM | 8.35 |
| CHEMBL45452 | — | Kd | = | 7.244 | nM | 8.14 |
| CHEMBL45452 | — | Kd | = | 8.71 | nM | 8.06 |
| CHEMBL45452 | — | Kd | = | 8.913 | nM | 8.05 |
| CHEMBL45454 | — | Kd | = | 10.23 | nM | 7.99 |
| CHEMBL45454 | — | Kd | = | 12.3 | nM | 7.91 |
| CHEMBL45125 | — | Kd | = | 37.15 | nM | 7.43 |
| CHEMBL40559 | — | Kd | = | 162.18 | nM | 6.79 |