Assay Detail
ADMET
CHEMBL633440
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Tested for antimuscarinic potency on guinea pig ileum
9
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Enantioselectivity of muscarinic antagonists. Isomeric 2-cyclohexyl-2-phenyl-5-[(dimethylamino)methyl]-1,3-oxathiolane methiodides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 8.22 | 8.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 8.91 |
| CHEMBL45454 | — | — | 3 | 8.79 |
| CHEMBL45452 | — | — | 3 | 8.57 |
| CHEMBL45125 | — | — | 1 | 7.92 |
| CHEMBL40559 | — | — | 1 | 7.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Kd | = | 1.23 | nM | 8.91 |
| CHEMBL45454 | — | Kd | = | 1.622 | nM | 8.79 |
| CHEMBL45452 | — | Kd | = | 2.692 | nM | 8.57 |
| CHEMBL45454 | — | Kd | = | 4.169 | nM | 8.38 |
| CHEMBL45452 | — | Kd | = | 5.495 | nM | 8.26 |
| CHEMBL45125 | — | Kd | = | 12.02 | nM | 7.92 |
| CHEMBL45454 | — | Kd | = | 13.8 | nM | 7.86 |
| CHEMBL45452 | — | Kd | = | 13.8 | nM | 7.86 |
| CHEMBL40559 | — | Kd | = | 37.15 | nM | 7.43 |