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Assay Detail

CHEMBL637903

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity towards adenosine A1 receptor
ChEMBL ↗
56
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Adenosine receptor A1 (CHEMBL318) ↗
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

N6-substituted adenosine receptor agonists: potential antihypertensive agents.
Trivedi BK, Blankley CJ, Bristol JA, Hamilton HW, Patt WC, Kramer WJ, Johnson SA, Bruns RF, Cohen DM, Ryan MJ.
J Med Chem (1991) 34 : 1043 -1049
PubMed 2002448 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 56 7.24 8.44

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2235597 — — 1 8.44
CHEMBL2235605 — — 1 8.30
CHEMBL2236001 — — 1 8.29
CHEMBL604141 — — 1 8.08
CHEMBL2092768 — — 3 7.92
CHEMBL2235595 — — 1 7.87
CHEMBL2235589 — — 1 7.76
CHEMBL2234029 — — 1 7.75
CHEMBL2236011 — — 1 7.69
CHEMBL2235600 — — 1 7.65
CHEMBL2236003 — — 1 7.64
CHEMBL2236012 — — 1 7.62
CHEMBL132960 — — 1 7.62
CHEMBL2235604 — — 1 7.62
CHEMBL2235590 — — 1 7.59
CHEMBL2235609 — — 1 7.55
CHEMBL2235608 — — 1 7.55
CHEMBL2235596 — — 1 7.50
CHEMBL605165 — — 1 7.49
CHEMBL2235607 — — 1 7.48
CHEMBL3350060 — — 1 7.47
CHEMBL2236006 — — 1 7.40
CHEMBL2235999 — — 1 7.39
CHEMBL2235611 — — 1 7.39
CHEMBL2235583 — — 1 7.38
CHEMBL2092765 — — 3 7.38
CHEMBL2235606 — — 1 7.37
CHEMBL2092767 — — 3 7.36
CHEMBL2235598 — — 1 7.34
CHEMBL2235603 — — 1 7.30

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2235597 — Ki = 3.6 nM 8.44
CHEMBL2235605 — Ki = 4.98 nM 8.30
CHEMBL2236001 — Ki = 5.19 nM 8.29
CHEMBL604141 — Ki = 8.39 nM 8.08
CHEMBL2092768 — Ki = 12.1 nM 7.92
CHEMBL2235595 — Ki = 13.6 nM 7.87
CHEMBL2235589 — Ki = 17.3 nM 7.76
CHEMBL2234029 — Ki = 17.8 nM 7.75
CHEMBL2236011 — Ki = 20.4 nM 7.69
CHEMBL2235600 — Ki = 22.2 nM 7.65
CHEMBL2236003 — Ki = 22.9 nM 7.64
CHEMBL2092768 — Ki = 22.9 nM 7.64
CHEMBL2236012 — Ki = 23.7 nM 7.62
CHEMBL2235604 — Ki = 23.8 nM 7.62
CHEMBL132960 — Ki = 24.0 nM 7.62
CHEMBL2235590 — Ki = 25.4 nM 7.59
CHEMBL2235609 — Ki = 28.0 nM 7.55
CHEMBL2235608 — Ki = 28.2 nM 7.55
CHEMBL2235596 — Ki = 31.9 nM 7.50
CHEMBL605165 — Ki = 32.4 nM 7.49
CHEMBL2235607 — Ki = 33.4 nM 7.48
CHEMBL3350060 — Ki = 33.7 nM 7.47
CHEMBL2236006 — Ki = 40.1 nM 7.40
CHEMBL2235611 — Ki = 41.0 nM 7.39
CHEMBL2235999 — Ki = 40.5 nM 7.39
CHEMBL2092765 — Ki = 41.7 nM 7.38
CHEMBL2235583 — Ki = 41.2 nM 7.38
CHEMBL2235606 — Ki = 42.3 nM 7.37
CHEMBL2092767 — Ki = 43.6 nM 7.36
CHEMBL2235598 — Ki = 45.8 nM 7.34
CHEMBL2092767 — Ki = 46.9 nM 7.33
CHEMBL2092767 — Ki = 48.3 nM 7.32
CHEMBL2235603 — Ki = 50.5 nM 7.30
CHEMBL2092765 — Ki = 59.5 nM 7.22
CHEMBL604144 — Ki = 61.3 nM 7.21
CHEMBL2235594 — Ki = 63.5 nM 7.20
CHEMBL2236000 — Ki = 68.0 nM 7.17
CHEMBL2236007 — Ki = 68.6 nM 7.16
CHEMBL2236005 — Ki = 71.5 nM 7.15
CHEMBL2235584 — Ki = 81.1 nM 7.09
CHEMBL2235585 — Ki = 87.9 nM 7.06
CHEMBL2235588 — Ki = 99.8 nM 7.00
CHEMBL2235610 — Ki = 104.0 nM 6.98
CHEMBL2235601 — Ki = 115.0 nM 6.94
CHEMBL2235593 — Ki = 118.0 nM 6.93
CHEMBL2235586 — Ki = 138.0 nM 6.86
CHEMBL2092765 — Ki = 236.0 nM 6.63
CHEMBL2235591 — Ki = 275.0 nM 6.56
CHEMBL2236002 — Ki = 299.0 nM 6.52
CHEMBL2235599 — Ki = 310.0 nM 6.51