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Compound Detail

CHEMBL2092768

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COc1ccc2c(c1)C(Nc1ncnc3c1ncn3[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O)CCC2

Basic Information

ChEMBL ID CHEMBL2092768
Phase Preclinical
Structure Type MOL
InChI Key PDCRQRXFQSQZOB-BWZSZYTASA-N
2
Targets
7
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

427.5
MW (Da)
0.94
ALogP
10
HBA
4
HBD
134.8
PSA (Ų)
0.47
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H25N5O5
MW 427.46
Aromatic Rings 3
Heavy Atoms 31
NP-Likeness 0.52

Activity Summary

Ki 7 meas. best 7.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 7.92 7.05 12.1 3
Adenosine A2 receptor
CHEMBL2094117
Ki 6.56 5.7467 274.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
2002448 10.1021/jm00107a025 Rattus norvegicus 6
2002448 10.1021/jm00107a025 Adenosine receptor A1 3
2002448 10.1021/jm00107a025 Adenosine A2 receptor 3
2002448 10.1021/jm00107a025 Adenosine receptors; A1 & A2 3
- 10.1007/s00044-010-9478-z Unchecked 1

Data from ChEMBL 36 via Core Engine