Assay Detail
Binding
CHEMBL645453
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Binding affinity towards adenosine A2 receptor
56
Total Activities
50
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
N6-substituted adenosine receptor agonists: potential antihypertensive agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 56 | 5.91 | 8.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL132960 | — | — | 1 | 8.03 |
| CHEMBL605165 | — | — | 1 | 7.36 |
| CHEMBL2235588 | — | — | 1 | 7.27 |
| CHEMBL2235596 | — | — | 1 | 7.23 |
| CHEMBL2236001 | — | — | 1 | 7.18 |
| CHEMBL2234029 | — | — | 1 | 7.11 |
| CHEMBL2235589 | — | — | 1 | 7.04 |
| CHEMBL2236006 | — | — | 1 | 6.80 |
| CHEMBL2236003 | — | — | 1 | 6.79 |
| CHEMBL2236011 | — | — | 1 | 6.76 |
| CHEMBL2236012 | — | — | 1 | 6.66 |
| CHEMBL2235597 | — | — | 1 | 6.64 |
| CHEMBL2092768 | — | — | 3 | 6.56 |
| CHEMBL3350060 | — | — | 1 | 6.49 |
| CHEMBL2235584 | — | — | 1 | 6.49 |
| CHEMBL604141 | — | — | 1 | 6.47 |
| CHEMBL2235594 | — | — | 1 | 6.47 |
| CHEMBL2235583 | — | — | 1 | 6.40 |
| CHEMBL2235600 | — | — | 1 | 6.38 |
| CHEMBL2235595 | — | — | 1 | 6.30 |
| CHEMBL2235586 | — | — | 1 | 6.29 |
| CHEMBL2235585 | — | — | 1 | 6.19 |
| CHEMBL2236000 | — | — | 1 | 6.18 |
| CHEMBL2235606 | — | — | 1 | 6.11 |
| CHEMBL2235593 | — | — | 1 | 6.07 |
| CHEMBL2235598 | — | — | 1 | 5.95 |
| CHEMBL2235590 | — | — | 1 | 5.91 |
| CHEMBL2235605 | — | — | 1 | 5.86 |
| CHEMBL2092765 | — | — | 3 | 5.84 |
| CHEMBL2235604 | — | — | 1 | 5.79 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL132960 | — | Ki | = | 9.4 | nM | 8.03 |
| CHEMBL605165 | — | Ki | = | 44.2 | nM | 7.36 |
| CHEMBL2235588 | — | Ki | = | 53.4 | nM | 7.27 |
| CHEMBL2235596 | — | Ki | = | 58.3 | nM | 7.23 |
| CHEMBL2236001 | — | Ki | = | 66.7 | nM | 7.18 |
| CHEMBL2234029 | — | Ki | = | 76.9 | nM | 7.11 |
| CHEMBL2235589 | — | Ki | = | 91.7 | nM | 7.04 |
| CHEMBL2236006 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL2236003 | — | Ki | = | 163.0 | nM | 6.79 |
| CHEMBL2236011 | — | Ki | = | 175.0 | nM | 6.76 |
| CHEMBL2236012 | — | Ki | = | 218.0 | nM | 6.66 |
| CHEMBL2235597 | — | Ki | = | 229.0 | nM | 6.64 |
| CHEMBL2092768 | — | Ki | = | 274.0 | nM | 6.56 |
| CHEMBL3350060 | — | Ki | = | 321.0 | nM | 6.49 |
| CHEMBL2235584 | — | Ki | = | 327.0 | nM | 6.49 |
| CHEMBL604141 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL2235594 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL2235583 | — | Ki | = | 396.0 | nM | 6.40 |
| CHEMBL2235600 | — | Ki | = | 412.0 | nM | 6.38 |
| CHEMBL2235595 | — | Ki | = | 496.0 | nM | 6.30 |
| CHEMBL2235586 | — | Ki | = | 511.0 | nM | 6.29 |
| CHEMBL2092768 | — | Ki | = | 619.0 | nM | 6.21 |
| CHEMBL2235585 | — | Ki | = | 642.0 | nM | 6.19 |
| CHEMBL2236000 | — | Ki | = | 666.0 | nM | 6.18 |
| CHEMBL2235606 | — | Ki | = | 769.0 | nM | 6.11 |
| CHEMBL2235593 | — | Ki | = | 857.0 | nM | 6.07 |
| CHEMBL2235598 | — | Ki | = | 1120.0 | nM | 5.95 |
| CHEMBL2235590 | — | Ki | = | 1234.0 | nM | 5.91 |
| CHEMBL2235605 | — | Ki | = | 1383.0 | nM | 5.86 |
| CHEMBL2092765 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL2235604 | — | Ki | = | 1642.0 | nM | 5.79 |
| CHEMBL605177 | — | Ki | = | 1821.0 | nM | 5.74 |
| CHEMBL2235611 | — | Ki | = | 1808.0 | nM | 5.74 |
| CHEMBL604144 | — | Ki | = | 1922.0 | nM | 5.72 |
| CHEMBL2235591 | — | Ki | = | 2705.0 | nM | 5.57 |
| CHEMBL2236005 | — | Ki | = | 2947.0 | nM | 5.53 |
| CHEMBL2235601 | — | Ki | = | 3002.0 | nM | 5.52 |
| CHEMBL2235999 | — | Ki | = | 3548.0 | nM | 5.45 |
| CHEMBL2092767 | — | Ki | = | 3946.0 | nM | 5.40 |
| CHEMBL2236002 | — | Ki | = | 3989.0 | nM | 5.40 |
| CHEMBL2092765 | — | Ki | = | 4350.0 | nM | 5.36 |
| CHEMBL2235603 | — | Ki | = | 4539.0 | nM | 5.34 |
| CHEMBL2235608 | — | Ki | = | 5302.0 | nM | 5.28 |
| CHEMBL2236007 | — | Ki | = | 5929.0 | nM | 5.23 |
| CHEMBL2092767 | — | Ki | = | 5922.0 | nM | 5.23 |
| CHEMBL2235607 | — | Ki | = | 7487.0 | nM | 5.13 |
| CHEMBL2235609 | — | Ki | = | 9038.0 | nM | 5.04 |
| CHEMBL2235610 | — | Ki | = | 12480.0 | nM | 4.90 |
| CHEMBL2235599 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL2092765 | — | Ki | = | 28260.0 | nM | 4.55 |