Assay Detail
Binding
CHEMBL638602
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Inhibitory concentration of compound against acetylcholinesterase from human erythrocytes at pH=8.0
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.42 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL173018 | — | — | 1 | 7.92 |
| CHEMBL609977 | — | — | 1 | 7.91 |
| CHEMBL173309 | — | — | 1 | 7.73 |
| CHEMBL176308 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL173018 | — | IC50 | = | 12.02 | nM | 7.92 |
| CHEMBL609977 | — | IC50 | = | 12.3 | nM | 7.91 |
| CHEMBL173309 | — | IC50 | = | 18.62 | nM | 7.73 |
| CHEMBL176308 | — | IC50 | = | 794.33 | nM | 6.10 |