Assay Detail
Functional
CHEMBL640340
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Tested for adenosine A1 receptor agonistic activity by determining concentration needed to prolong the stimulus-QRS interval by 50% of the maximum response
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2-(N'-aralkylidenehydrazino)adenosines: potent and selective coronary vasodilators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 31 | 4.69 | 6.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL608175 | — | — | 1 | 6.08 |
| CHEMBL611920 | — | — | 1 | 5.58 |
| CHEMBL611609 | — | — | 1 | 5.52 |
| CHEMBL608174 | — | — | 1 | 5.38 |
| CHEMBL607590 | — | — | 1 | 5.05 |
| CHEMBL607508 | — | — | 1 | 5.04 |
| CHEMBL607886 | — | — | 1 | 4.92 |
| CHEMBL608167 | — | — | 1 | 4.91 |
| CHEMBL611947 | — | — | 1 | 4.90 |
| CHEMBL2326842 | — | — | 1 | 4.85 |
| CHEMBL607511 | — | — | 1 | 4.77 |
| CHEMBL607872 | — | — | 1 | 4.72 |
| CHEMBL608451 | — | — | 1 | 4.71 |
| CHEMBL610444 | — | — | 1 | 4.70 |
| CHEMBL2326828 | — | — | 1 | 4.64 |
| CHEMBL607798 | — | — | 1 | 4.58 |
| CHEMBL607604 | — | — | 1 | 4.51 |
| CHEMBL608447 | — | — | 1 | 4.49 |
| CHEMBL611571 | — | — | 1 | 4.40 |
| CHEMBL608448 | — | — | 1 | 4.38 |
| CHEMBL611918 | — | — | 1 | 4.38 |
| CHEMBL608176 | — | — | 1 | 4.38 |
| CHEMBL608668 | — | — | 1 | 4.36 |
| CHEMBL609338 | — | — | 1 | 4.31 |
| CHEMBL607605 | — | — | 1 | 4.31 |
| CHEMBL607797 | — | — | 1 | 4.24 |
| CHEMBL610445 | — | — | 1 | 4.22 |
| CHEMBL607891 | — | — | 1 | 4.18 |
| CHEMBL607592 | — | — | 1 | 4.08 |
| CHEMBL607874 | — | — | 1 | 4.08 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL608175 | — | EC50 | = | 831.76 | nM | 6.08 |
| CHEMBL611920 | — | EC50 | = | 2630.27 | nM | 5.58 |
| CHEMBL611609 | — | EC50 | = | 3019.95 | nM | 5.52 |
| CHEMBL608174 | — | EC50 | = | 4168.69 | nM | 5.38 |
| CHEMBL607590 | — | EC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL607508 | — | EC50 | = | 9120.11 | nM | 5.04 |
| CHEMBL607886 | — | EC50 | = | 12022.64 | nM | 4.92 |
| CHEMBL608167 | — | EC50 | = | 12302.69 | nM | 4.91 |
| CHEMBL611947 | — | EC50 | = | 12589.25 | nM | 4.90 |
| CHEMBL2326842 | — | EC50 | = | 14125.38 | nM | 4.85 |
| CHEMBL607511 | — | EC50 | = | 16982.44 | nM | 4.77 |
| CHEMBL607872 | — | EC50 | = | 19054.61 | nM | 4.72 |
| CHEMBL608451 | — | EC50 | = | 19498.45 | nM | 4.71 |
| CHEMBL610444 | — | EC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL2326828 | — | EC50 | = | 22908.68 | nM | 4.64 |
| CHEMBL607798 | — | EC50 | = | 26302.68 | nM | 4.58 |
| CHEMBL607604 | — | EC50 | = | 30902.95 | nM | 4.51 |
| CHEMBL608447 | — | EC50 | = | 32359.37 | nM | 4.49 |
| CHEMBL611571 | — | EC50 | = | 39810.72 | nM | 4.40 |
| CHEMBL608448 | — | EC50 | = | 41686.94 | nM | 4.38 |
| CHEMBL611918 | — | EC50 | = | 41686.94 | nM | 4.38 |
| CHEMBL608176 | — | EC50 | = | 41686.94 | nM | 4.38 |
| CHEMBL608668 | — | EC50 | = | 43651.58 | nM | 4.36 |
| CHEMBL609338 | — | EC50 | = | 48977.88 | nM | 4.31 |
| CHEMBL607605 | — | EC50 | = | 48977.88 | nM | 4.31 |
| CHEMBL607797 | — | EC50 | = | 57543.99 | nM | 4.24 |
| CHEMBL610445 | — | EC50 | = | 60255.96 | nM | 4.22 |
| CHEMBL607891 | — | EC50 | = | 66069.34 | nM | 4.18 |
| CHEMBL607592 | — | EC50 | = | 83176.38 | nM | 4.08 |
| CHEMBL607874 | — | EC50 | = | 83176.38 | nM | 4.08 |
| CHEMBL88070 | — | EC50 | = | 112201.85 | nM | - |