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Compound Detail

CHEMBL608174

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C/C(=N\Nc1nc(N)c2ncn(C3O[C@H](CO)[C@@H](O)[C@H]3O)c2n1)c1ccc(F)cc1

Basic Information

ChEMBL ID CHEMBL608174
Phase Preclinical
Structure Type MOL
InChI Key DOQXNVBLKUFUIH-WGVRSDFZSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

417.4
MW (Da)
0.00
ALogP
11
HBA
5
HBD
163.9
PSA (Ų)
0.28
QED
1
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H20FN7O4
MW 417.40
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -0.11

Activity Summary

EC50 2 meas. best 8.49

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine A2 receptor
CHEMBL2094257
EC50 8.49 8.49 3.2 1
Adenosine receptor A1
CHEMBL2304404
EC50 5.38 5.38 4168.7 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1469688 10.1021/jm00102a008 Adenosine receptor A1 1
1469688 10.1021/jm00102a008 Adenosine A2 receptor 1
1469688 10.1021/jm00102a008 Adenosine receptors; A1 & A2 1

Data from ChEMBL 36 via Core Engine