Assay Detail
Binding
CHEMBL640359
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Binding affinity for adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Subcellular | Brain membranes |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Ribose-modified adenosine analogues as adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 18 | 6.30 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139000 | (R)-PIA | — | 1 | 8.96 |
| CHEMBL611892 | — | — | 1 | 8.80 |
| CHEMBL607763 | — | — | 1 | 7.60 |
| CHEMBL2112569 | — | — | 1 | 7.54 |
| CHEMBL610691 | — | — | 1 | 7.54 |
| CHEMBL325664 | — | — | 1 | 5.92 |
| CHEMBL118802 | — | — | 1 | 5.82 |
| CHEMBL2112121 | — | — | 1 | 5.72 |
| CHEMBL332331 | — | — | 1 | 5.24 |
| CHEMBL118785 | — | — | 1 | 5.02 |
| CHEMBL331957 | — | — | 1 | 4.82 |
| CHEMBL2111777 | — | — | 1 | 4.70 |
| CHEMBL117739 | — | — | 1 | 4.17 |
| CHEMBL118435 | — | — | 1 | - |
| CHEMBL609528 | — | — | 1 | - |
| CHEMBL325192 | — | — | 1 | - |
| CHEMBL120075 | — | — | 1 | - |
| CHEMBL332668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139000 | (R)-PIA | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL611892 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL607763 | — | Ki | = | 25.0 | nM | 7.60 |
| CHEMBL2112569 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL610691 | — | Ki | = | 29.0 | nM | 7.54 |
| CHEMBL325664 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL118802 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL2112121 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL332331 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL118785 | — | Ki | = | 9600.0 | nM | 5.02 |
| CHEMBL331957 | — | Ki | = | 15000.0 | nM | 4.82 |
| CHEMBL2111777 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL117739 | — | Ki | = | 68000.0 | nM | 4.17 |
| CHEMBL118435 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL609528 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL325192 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL120075 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL332668 | — | Ki | > | 2200.0 | nM | - |