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Compound Detail

CHEMBL325664

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C[C@H](Cc1ccccc1)Nc1ncnc2c1ncn2C1CCCCO1

Basic Information

ChEMBL ID CHEMBL325664
Phase Preclinical
Structure Type MOL
InChI Key AELLXJKOLLIMNZ-IURRXHLWSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

337.4
MW (Da)
3.57
ALogP
6
HBA
1
HBD
64.9
PSA (Ų)
0.77
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C19H23N5O
MW 337.43
Aromatic Rings 3
Heavy Atoms 25
NP-Likeness -0.35

Activity Summary

Ki 2 meas. best 5.92

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A1
CHEMBL318
Ki 5.92 5.92 1200.0 1
Adenosine A2 receptor
CHEMBL2094117
Ki 4.42 4.42 38000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
3005574 10.1021/jm00153a008 Mus musculus 2
3005574 10.1021/jm00153a008 Rattus norvegicus 2
3005574 10.1021/jm00153a008 Adenosine receptor A1 1
3005574 10.1021/jm00153a008 Adenosine A2 receptor 1
3005574 10.1021/jm00153a008 Adenosine receptors; A1 & A2 1

Data from ChEMBL 36 via Core Engine