Assay Detail
Binding
CHEMBL646478
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Binding affinity for adenosine A2 receptor in rat striatal membranes using [3H]NECA as radioligand
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Striatum |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Ribose-modified adenosine analogues as adenosine receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 5.18 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139000 | (R)-PIA | — | 1 | 6.92 |
| CHEMBL611892 | — | — | 1 | 5.72 |
| CHEMBL607763 | — | — | 1 | 5.48 |
| CHEMBL2112569 | — | — | 1 | 5.16 |
| CHEMBL118802 | — | — | 1 | 5.09 |
| CHEMBL325664 | — | — | 1 | 4.42 |
| CHEMBL118785 | — | — | 1 | 4.41 |
| CHEMBL610691 | — | — | 1 | 4.25 |
| CHEMBL332668 | — | — | 1 | - |
| CHEMBL325192 | — | — | 1 | - |
| CHEMBL609528 | — | — | 1 | - |
| CHEMBL331957 | — | — | 1 | - |
| CHEMBL118435 | — | — | 1 | - |
| CHEMBL332331 | — | — | 1 | - |
| CHEMBL2111777 | — | — | 1 | - |
| CHEMBL120075 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139000 | (R)-PIA | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL611892 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL607763 | — | Ki | = | 3300.0 | nM | 5.48 |
| CHEMBL2112569 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL118802 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL325664 | — | Ki | = | 38000.0 | nM | 4.42 |
| CHEMBL118785 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL610691 | — | Ki | = | 56000.0 | nM | 4.25 |
| CHEMBL332668 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL325192 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL609528 | — | Ki | > | 50000.0 | nM | - |
| CHEMBL331957 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL118435 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL332331 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL2111777 | — | Ki | > | 100000.0 | nM | - |
| CHEMBL120075 | — | Ki | > | 10000.0 | nM | - |