Assay Detail
Functional
CHEMBL640394
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against HIV in Alex cells
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human immunodeficiency virus |
| Cell Type | Alex |
| Confidence | 1 — Organism |
| Curated By | Expert |
Target
Human immunodeficiency virus (CHEMBL613758) ↗| Type | ORGANISM |
| Organism | Human immunodeficiency virus |
Publication
Synthesis and antiviral activity of some acyclic and C-acyclic pyrrolo[2,3-d]pyrimidine nucleoside analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.21 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | 4.0 | 1 | 8.00 |
| CHEMBL68274 | — | — | 1 | 5.52 |
| CHEMBL50879 | — | — | 1 | 4.70 |
| CHEMBL69767 | — | — | 1 | 4.70 |
| CHEMBL33236 | — | — | 1 | 4.34 |
| CHEMBL71564 | — | — | 1 | 4.00 |
| CHEMBL431178 | — | — | 1 | - |
| CHEMBL71190 | — | — | 1 | - |
| CHEMBL305439 | — | — | 1 | - |
| CHEMBL302081 | — | — | 1 | - |
| CHEMBL302072 | — | — | 1 | - |
| CHEMBL66632 | — | — | 1 | - |
| CHEMBL302065 | — | — | 1 | - |
| CHEMBL69223 | — | — | 1 | - |
| CHEMBL302080 | — | — | 1 | - |
| CHEMBL68543 | — | — | 1 | - |
| CHEMBL67494 | — | — | 1 | - |
| CHEMBL68508 | — | — | 1 | - |
| CHEMBL308972 | — | — | 1 | - |
| CHEMBL303191 | — | — | 1 | - |
| CHEMBL68040 | — | — | 1 | - |
| CHEMBL69225 | — | — | 1 | - |
| CHEMBL69314 | — | — | 1 | - |
| CHEMBL306876 | — | — | 1 | - |
| CHEMBL306885 | — | — | 1 | - |
| CHEMBL69206 | — | — | 1 | - |
| CHEMBL51484 | — | — | 1 | - |
| CHEMBL307763 | — | — | 1 | - |
| CHEMBL305027 | — | — | 1 | - |
| CHEMBL305256 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL129 | ZIDOVUDINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL68274 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL50879 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL69767 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL33236 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL71564 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL305439 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL34163 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL302081 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL302072 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL66632 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL302065 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL69223 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL302080 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL68543 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL67494 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL68508 | — | IC50 | = | 197000.0 | nM | - |
| CHEMBL71190 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL68929 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL431178 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL308972 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL303191 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL68040 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL69225 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL69314 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL306876 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL306885 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL69206 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL51484 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL307763 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL305027 | — | IC50 | > | 200000.0 | nM | - |
| CHEMBL305256 | — | IC50 | > | 200000.0 | nM | - |