Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL640432

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatum
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Rattus norvegicus
Confidence 9 — Direct single protein target
Curated By Expert

Target

Adenosine receptor A2a (CHEMBL302)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

2-[N'-(3-arylallylidene)hydrazino]adenosines showing A2a adenosine agonist properties and vasodilation activity.
Viziano M, Ongini E, Conti A, Zocchi C, Seminati M, Pocar D.
J Med Chem (1995) 38 : 3581 -3585
PubMed 7658444 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 14 7.28 8.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL464859 NECA 1 8.11
CHEMBL331372 CGS-21680 1 7.96
CHEMBL2113556 1 7.64
CHEMBL2113559 1 7.57
CHEMBL611571 1 7.54
CHEMBL2113563 1 7.42
CHEMBL2113564 1 7.38
CHEMBL2113558 1 7.27
CHEMBL2113560 1 7.23
CHEMBL2113555 1 7.08
CHEMBL2113553 1 6.77
CHEMBL2113554 1 6.42
CHEMBL284969 1 6.19
CHEMBL2113552 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL464859 NECA Ki = 7.8 nM 8.11
CHEMBL331372 CGS-21680 Ki = 11.0 nM 7.96
CHEMBL2113556 Ki = 23.0 nM 7.64
CHEMBL2113559 Ki = 27.0 nM 7.57
CHEMBL611571 Ki = 29.0 nM 7.54
CHEMBL2113563 Ki = 38.0 nM 7.42
CHEMBL2113564 Ki = 42.0 nM 7.38
CHEMBL2113558 Ki = 54.0 nM 7.27
CHEMBL2113560 Ki = 59.0 nM 7.23
CHEMBL2113555 Ki = 83.0 nM 7.08
CHEMBL2113553 Ki = 170.0 nM 6.77
CHEMBL2113554 Ki = 384.0 nM 6.42
CHEMBL284969 Ki = 650.0 nM 6.19
CHEMBL2113552 Ki > 1000.0 nM -