Assay Detail
Binding
CHEMBL640473
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Displacement of [3H]CHA from Adenosine A1 receptor of rat brain
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2-alkenyl and 2-alkyl derivatives of adenosine and adenosine-5'-N-ethyluronamide: different affinity and selectivity of E- and Z-diastereomers at A2A adenosine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.63 | 7.98 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL464859 | NECA | — | 1 | 7.98 |
| CHEMBL319387 | — | — | 1 | 7.01 |
| CHEMBL2113526 | — | — | 1 | 6.93 |
| CHEMBL410873 | — | — | 1 | 6.89 |
| CHEMBL2113450 | — | — | 1 | 6.68 |
| CHEMBL2113528 | — | — | 1 | 6.60 |
| CHEMBL98603 | — | — | 1 | 6.48 |
| CHEMBL2113527 | — | — | 1 | 6.21 |
| CHEMBL223270 | — | — | 1 | 6.16 |
| CHEMBL611256 | — | — | 1 | 6.02 |
| CHEMBL2304158 | — | — | 1 | 5.99 |
| CHEMBL2113529 | — | — | 1 | - |
| CHEMBL608918 | — | — | 1 | - |
| CHEMBL2113525 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL464859 | NECA | Ki | = | 10.4 | nM | 7.98 |
| CHEMBL319387 | — | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL2113526 | — | Ki | = | 117.0 | nM | 6.93 |
| CHEMBL410873 | — | Ki | = | 130.0 | nM | 6.89 |
| CHEMBL2113450 | — | Ki | = | 209.0 | nM | 6.68 |
| CHEMBL2113528 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL98603 | — | Ki | = | 332.0 | nM | 6.48 |
| CHEMBL2113527 | — | Ki | = | 618.0 | nM | 6.21 |
| CHEMBL223270 | — | Ki | = | 698.0 | nM | 6.16 |
| CHEMBL611256 | — | Ki | = | 951.0 | nM | 6.02 |
| CHEMBL2304158 | — | Ki | = | 1017.0 | nM | 5.99 |
| CHEMBL2113529 | — | Ki | > | 1.0 | nM | - |
| CHEMBL608918 | — | Ki | > | 1.0 | nM | - |
| CHEMBL2113525 | — | Ki | > | 1.0 | nM | - |