Assay Detail
Binding
CHEMBL641042
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CHA from Adenosine A1 receptor of rat forebrain membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Adenosine A2A antagonists with potent anti-cataleptic activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 6.56 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77699 | — | — | 1 | 7.43 |
| CHEMBL77698 | — | — | 1 | 7.11 |
| CHEMBL77691 | — | — | 1 | 6.96 |
| CHEMBL76931 | — | — | 1 | 6.82 |
| CHEMBL283937 | — | — | 1 | 6.80 |
| CHEMBL312079 | — | — | 1 | 6.66 |
| CHEMBL306633 | — | — | 1 | 6.47 |
| CHEMBL27508 | — | — | 1 | 6.41 |
| CHEMBL78317 | — | — | 1 | 6.25 |
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | 6.24 |
| CHEMBL306313 | — | — | 1 | 5.96 |
| CHEMBL73827 | — | — | 1 | 5.60 |
| CHEMBL306945 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77699 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL77698 | — | Ki | = | 78.0 | nM | 7.11 |
| CHEMBL77691 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL76931 | — | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL283937 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL312079 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL306633 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL27508 | — | Ki | = | 390.0 | nM | 6.41 |
| CHEMBL78317 | — | Ki | = | 560.0 | nM | 6.25 |
| CHEMBL431770 | ISTRADEFYLLINE | Ki | = | 580.0 | nM | 6.24 |
| CHEMBL306313 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL73827 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL306945 | — | Ki | > | 100000.0 | nM | - |