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Compound Detail

CHEMBL306633

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CCCn1c(=O)c2c(nc(/C=C/c3ccc(OC)cc3)n2C)n(CCC)c1=O

Basic Information

ChEMBL ID CHEMBL306633
Phase Preclinical
Structure Type MOL
InChI Key YADAAFDDAMXDEJ-FMIVXFBMSA-N
4
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names

Molecular Properties

382.5
MW (Da)
2.90
ALogP
7
HBA
0
HBD
71.0
PSA (Ų)
0.63
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C21H26N4O3
MW 382.46
Aromatic Rings 3
Heavy Atoms 28
NP-Likeness -0.84

Activity Summary

Ki 7 meas. best 8.35

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Adenosine receptor A2a
CHEMBL302
Ki 8.35 8.05 4.5 2
Adenosine A2 receptor
CHEMBL2094117
Ki 7.75 7.75 18.0 1
Adenosine receptor A1
CHEMBL318
Ki 7.2 6.7133 63.0 3
Adenosine receptor A1
CHEMBL2304404
Ki 5.85 5.85 1400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
- 10.1016/S0960-894X(97)00440-X Adenosine receptor A1 2
- 10.1016/S0960-894X(97)00440-X Adenosine receptor A2a 2
- 10.1016/S0960-894X(97)00440-X Adenosine receptors; A1 & A2a 2
1613758 10.1021/jm00090a027 Adenosine receptor A1 2
- 10.1016/S0960-894X(97)00440-X Mus musculus 1
1613758 10.1021/jm00090a027 Adenosine A2 receptor 1
1613758 10.1021/jm00090a027 Unchecked 1

Data from ChEMBL 36 via Core Engine