Assay Detail
Binding
CHEMBL645016
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Displacement of [3H]CHA from Adenosine A1 receptor of rat forebrain membranes (shielded from light)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Adenosine A2A antagonists with potent anti-cataleptic activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.97 | 7.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL27508 | — | — | 1 | 7.21 |
| CHEMBL77699 | — | — | 1 | 7.21 |
| CHEMBL306633 | — | — | 1 | 7.20 |
| CHEMBL77691 | — | — | 1 | 7.08 |
| CHEMBL312079 | — | — | 1 | 7.00 |
| CHEMBL77698 | — | — | 1 | 6.92 |
| CHEMBL306313 | — | — | 1 | 6.92 |
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | 6.82 |
| CHEMBL75093 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL27508 | — | Ki | = | 62.0 | nM | 7.21 |
| CHEMBL77699 | — | Ki | = | 61.0 | nM | 7.21 |
| CHEMBL306633 | — | Ki | = | 63.0 | nM | 7.20 |
| CHEMBL77691 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL312079 | — | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL77698 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL306313 | — | Ki | = | 120.0 | nM | 6.92 |
| CHEMBL431770 | ISTRADEFYLLINE | Ki | = | 150.0 | nM | 6.82 |
| CHEMBL75093 | — | Ki | = | 470.0 | nM | 6.33 |