Assay Detail
Binding
CHEMBL647730
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Displacement of [3H]-CGS- 21680 from Adenosine A2a receptor of rat forebrain membranes (shielded from light)
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Adenosine A2A antagonists with potent anti-cataleptic activity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 8.62 | 9.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77691 | — | — | 1 | 9.17 |
| CHEMBL77698 | — | — | 1 | 9.17 |
| CHEMBL27508 | — | — | 1 | 9.00 |
| CHEMBL306313 | — | — | 1 | 8.77 |
| CHEMBL77699 | — | — | 1 | 8.66 |
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | 8.66 |
| CHEMBL422399 | — | — | 1 | 8.62 |
| CHEMBL306633 | — | — | 1 | 8.35 |
| CHEMBL312079 | — | — | 1 | 8.31 |
| CHEMBL75093 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77691 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL77698 | — | Ki | = | 0.67 | nM | 9.17 |
| CHEMBL27508 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL306313 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL77699 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL431770 | ISTRADEFYLLINE | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL422399 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL306633 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL312079 | — | Ki | = | 4.9 | nM | 8.31 |
| CHEMBL75093 | — | Ki | = | 35.0 | nM | 7.46 |