Assay Detail
Binding
CHEMBL643471
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Binding affinity against adenosine A1 receptor from rat forebrain membranes using N6-[3H]cyclohexyladenosine
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
(E)-1,3-dialkyl-7-methyl-8-(3,4,5-trimethoxystyryl)xanthines: potent and selective adenosine A2 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.58 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL283908 | — | — | 1 | 7.46 |
| CHEMBL312079 | — | — | 1 | 6.66 |
| CHEMBL306633 | — | — | 1 | 6.47 |
| CHEMBL27508 | — | — | 1 | 6.37 |
| CHEMBL306313 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL283908 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL312079 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL306633 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL27508 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL306313 | — | Ki | = | 1100.0 | nM | 5.96 |