Assay Detail
Binding
CHEMBL641302
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]CGS-21680 from Adenosine A2A receptor of rat striatal membrane at 10e-4 uM
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Chiral resolution and stereospecificity of 6-phenyl-4-phenylethynyl- 1,4-dihydropyridines as selective A(3) adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 4.61 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315984 | — | — | 1 | 5.32 |
| CHEMBL105672 | — | — | 1 | 4.46 |
| CHEMBL283013 | — | — | 1 | 4.06 |
| CHEMBL405355 | NIGULDIPINE | 2.0 | 1 | - |
| CHEMBL2051956 | DEXNIGULDIPINE | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315984 | — | Ki | = | 4770.0 | nM | 5.32 |
| CHEMBL105672 | — | Ki | = | 35100.0 | nM | 4.46 |
| CHEMBL283013 | — | Ki | = | 86300.0 | nM | 4.06 |
| CHEMBL405355 | NIGULDIPINE | Ki | > | 100000.0 | nM | - |
| CHEMBL2051956 | DEXNIGULDIPINE | Ki | > | 100000.0 | nM | - |