Assay Detail
Binding
CHEMBL641312
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-CGS- 21680 from Adenosine A2A receptor of rat striatal membranes
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N6,5'-Disubstituted adenosine derivatives as partial agonists for the human adenosine A3 receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 5.99 | 6.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL66393 | — | — | 1 | 6.47 |
| CHEMBL2113422 | — | — | 1 | 6.34 |
| CHEMBL2113433 | — | — | 1 | 6.19 |
| CHEMBL388757 | N6-BENZYLADENOSINE | — | 1 | 6.13 |
| CHEMBL2113428 | — | — | 1 | 5.97 |
| CHEMBL2113427 | — | — | 1 | 5.74 |
| CHEMBL2113429 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL66393 | — | Ki | = | 340.0 | nM | 6.47 |
| CHEMBL2113422 | — | Ki | = | 457.0 | nM | 6.34 |
| CHEMBL2113433 | — | Ki | = | 641.0 | nM | 6.19 |
| CHEMBL388757 | N6-BENZYLADENOSINE | Ki | = | 733.0 | nM | 6.13 |
| CHEMBL2113428 | — | Ki | = | 1081.0 | nM | 5.97 |
| CHEMBL2113427 | — | Ki | = | 1825.0 | nM | 5.74 |
| CHEMBL2113429 | — | Ki | = | 7990.0 | nM | 5.10 |