Assay Detail
Binding
CHEMBL641314
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Displacement of [3H]-CGS-21,680 or [3H]ZM-241385 binding in adenosine A2A receptor of rat striatal membrane was determined
11
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 11 | 5.64 | 6.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL164745 | — | — | 1 | 6.24 |
| CHEMBL164422 | — | — | 1 | 6.04 |
| CHEMBL162808 | — | — | 1 | 5.89 |
| CHEMBL163040 | — | — | 1 | 5.89 |
| CHEMBL165971 | — | — | 2 | 5.72 |
| CHEMBL60156 | — | — | 1 | 5.72 |
| CHEMBL305322 | — | — | 1 | 5.64 |
| CHEMBL165783 | — | — | 1 | 5.36 |
| CHEMBL164087 | — | — | 1 | 5.06 |
| CHEMBL354004 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL164745 | — | Ki | = | 570.0 | nM | 6.24 |
| CHEMBL164422 | — | Ki | = | 920.0 | nM | 6.04 |
| CHEMBL162808 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL163040 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL165971 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL60156 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL165971 | — | Ki | = | 2000.0 | nM | 5.70 |
| CHEMBL305322 | — | Ki | = | 2300.0 | nM | 5.64 |
| CHEMBL165783 | — | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL164087 | — | Ki | = | 8700.0 | nM | 5.06 |
| CHEMBL354004 | — | Ki | = | 15000.0 | nM | 4.82 |