Assay Detail
Binding
CHEMBL641439
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Displacement of [125I]AB-MECA from rat Adenosine A3 receptor expressed in CHO cell membrane
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Tetrahydrobenzothiophenone derivatives as a novel class of adenosine receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 4.70 | 4.99 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL130707 | — | — | 1 | 4.99 |
| CHEMBL75126 | — | — | 1 | 4.88 |
| CHEMBL335334 | — | — | 1 | 4.82 |
| CHEMBL337243 | — | — | 1 | 4.81 |
| CHEMBL336968 | — | — | 1 | 4.38 |
| CHEMBL2112672 | — | — | 1 | 4.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL130707 | — | Ki | = | 10200.0 | nM | 4.99 |
| CHEMBL75126 | — | Ki | = | 13100.0 | nM | 4.88 |
| CHEMBL335334 | — | Ki | = | 15200.0 | nM | 4.82 |
| CHEMBL337243 | — | Ki | = | 15400.0 | nM | 4.81 |
| CHEMBL336968 | — | Ki | = | 42000.0 | nM | 4.38 |
| CHEMBL2112672 | — | Ki | = | 51800.0 | nM | 4.29 |